OrangerV1, Main, Exploration, bibRecord, 000C34

In Vitro Photodynamic Inactivation of Plant-Pathogenic Fungi Colletotrichum acutatum and Colletotrichum gloeosporioides with Novel Phenothiazinium Photosensitizers

Identifieur interne : 000C34 ( Main/Exploration ); précédent : 000C33; suivant : 000C35

In Vitro Photodynamic Inactivation of Plant-Pathogenic Fungi Colletotrichum acutatum and Colletotrichum gloeosporioides with Novel Phenothiazinium Photosensitizers

Auteurs : Henrique D. De Menezes [Brésil] ; Gabriela B. Rodrigues [Brésil] ; Simone De Pádua Teixeira [Brésil] ; Nelson S. Massola [Brésil] ; Luciano Bachmann [Brésil] ; Mark Wainwright [Royaume-Uni] ; Gilberto U. L. Braga [Brésil]

Source :

Applied and Environmental Microbiology [ 0099-2240 ] ; 2014.

RBID : PMC:3957600

English descriptors

KwdEn :
- Antifungal Agents (pharmacology), Aspergillus nidulans (drug effects), Aspergillus nidulans (physiology), Citrus sinensis (microbiology), Colletotrichum (drug effects), Colletotrichum (physiology), Fungi, Microbial Sensitivity Tests, Microbial Viability (drug effects), Phenothiazines (pharmacology), Photosensitizing Agents (pharmacology), Spores, Fungal (drug effects).
MESH :
- chemical , pharmacology : Antifungal Agents, Phenothiazines, Photosensitizing Agents.
- drug effects : Aspergillus nidulans, Colletotrichum, Microbial Viability, Spores, Fungal.
- microbiology : Citrus sinensis.
- physiology : Aspergillus nidulans, Colletotrichum.
- Fungi, Microbial Sensitivity Tests.

Abstract

The increasing tolerance to currently used fungicides in both clinical and agricultural areas is of great concern. The nonconventional light-based approach of antimicrobial photodynamic treatment (APDT) is a promising alternative to conventional fungicides. We evaluated the effects of APDT with four phenothiazinium derivatives (methylene blue [MB], new methylene blue N [NMBN], toluidine blue O [TBO], and the novel pentacyclic phenothiazinium photosensitizer [PS] S137) on conidia of three fungal species (Colletotrichum acutatum, Colletotrichum gloeosporioides, and Aspergillus nidulans). The efficacy of APDT with each PS was determined, initially, based on photosensitizer MICs. Additionally, the effects of APDT with two selected PSs (NMBN and S137) on survival of conidia were evaluated. The subcellular localization of the PS in C. acutatum conidia was determined. The effects of photodynamic treatments on leaves of the plant host Citrus sinensis were also investigated. APDT with S137 showed the lowest MIC. MICs for S137 were 5 μM for the three fungal species when a fluence of 25 J cm⁻² was used. APDT with NMBN (50 μM) and S137 (10 μM) resulted in a reduction in the survival of the conidia of all species of approximately 5 logs with fluences of ≥15 J cm⁻². Washing of the conidia before light exposure did not prevent photodynamic inactivation. Both NMBN and S137 accumulated in cytoplasmic structures, such as lipid bodies, of C. acutatum conidia. No damage to orange tree leaves was observed after APDT.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957600

DOI: 10.1128/AEM.02788-13
PubMed: 24362436
PubMed Central: 3957600

Affiliations:

Le document en format XML

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 Photodynamic Inactivation of Plant-Pathogenic Fungi <named-content content-type="genus-species">Colletotrichum acutatum</named-content>
 and <named-content content-type="genus-species">Colletotrichum gloeosporioides</named-content>
 with Novel Phenothiazinium Photosensitizers</title>
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 Photodynamic Inactivation of Plant-Pathogenic Fungi <named-content content-type="genus-species">Colletotrichum acutatum</named-content>
 and <named-content content-type="genus-species">Colletotrichum gloeosporioides</named-content>
 with Novel Phenothiazinium Photosensitizers</title>
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<front><div type="abstract" xml:lang="en"><p>The increasing tolerance to currently used fungicides in both clinical and agricultural areas is of great concern. The nonconventional light-based approach of antimicrobial photodynamic treatment (APDT) is a promising alternative to conventional fungicides. We evaluated the effects of APDT with four phenothiazinium derivatives (methylene blue [MB], new methylene blue N [NMBN], toluidine blue O [TBO], and the novel pentacyclic phenothiazinium photosensitizer [PS] S137) on conidia of three fungal species (<named-content content-type="genus-species">Colletotrichum acutatum</named-content>
, <named-content content-type="genus-species">Colletotrichum gloeosporioides</named-content>
, and <named-content content-type="genus-species">Aspergillus nidulans</named-content>
). The efficacy of APDT with each PS was determined, initially, based on photosensitizer MICs. Additionally, the effects of APDT with two selected PSs (NMBN and S137) on survival of conidia were evaluated. The subcellular localization of the PS in <named-content content-type="genus-species">C. acutatum</named-content>
 conidia was determined. The effects of photodynamic treatments on leaves of the plant host <named-content content-type="genus-species">Citrus sinensis</named-content>
 were also investigated. APDT with S137 showed the lowest MIC. MICs for S137 were 5 μM for the three fungal species when a fluence of 25 J cm<sup>−2</sup>
 was used. APDT with NMBN (50 μM) and S137 (10 μM) resulted in a reduction in the survival of the conidia of all species of approximately 5 logs with fluences of ≥15 J cm<sup>−2</sup>
. Washing of the conidia before light exposure did not prevent photodynamic inactivation. Both NMBN and S137 accumulated in cytoplasmic structures, such as lipid bodies, of <named-content content-type="genus-species">C. acutatum</named-content>
 conidia. No damage to orange tree leaves was observed after APDT.</p>
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<name sortKey="Massola, Nelson S" sort="Massola, Nelson S" uniqKey="Massola N" first="Nelson S." last="Massola">Nelson S. Massola</name>
<name sortKey="Rodrigues, Gabriela B" sort="Rodrigues, Gabriela B" uniqKey="Rodrigues G" first="Gabriela B." last="Rodrigues">Gabriela B. Rodrigues</name>
<name sortKey="Teixeira, Simone De Padua" sort="Teixeira, Simone De Padua" uniqKey="Teixeira S" first="Simone De Pádua" last="Teixeira">Simone De Pádua Teixeira</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Wainwright, Mark" sort="Wainwright, Mark" uniqKey="Wainwright M" first="Mark" last="Wainwright">Mark Wainwright</name>
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In Vitro Photodynamic Inactivation of Plant-Pathogenic Fungi Colletotrichum acutatum and Colletotrichum gloeosporioides with Novel Phenothiazinium Photosensitizers

In Vitro Photodynamic Inactivation of Plant-Pathogenic Fungi Colletotrichum acutatum and Colletotrichum gloeosporioides with Novel Phenothiazinium Photosensitizers

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